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Gangrene of All Four Limbs in a Patient with Pemphigus Vulgaris Following Norepinephrine Use; A Rare Complication: Case Report
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Neda Nayebi    , Fataneh Ranjbar * |
| Emergency Nursing Specialist, Department of Nursing, Damavand Branch, Islamic Azad University, Damavand, Iran , fatane.ranjbar333@gmail.com |
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Abstract: (16 Views) |
Background & aim: The use of epinephrine in a patient with pemphigus vulgaris, characterized by flaccid and erosive blisters of the skin and mucous membranes, led to infection and gangrene of all four limbs.
Case Report: This report describes a rare case of gangrene affecting all four limbs in a 59-year- old woman with pemphigus vulgaris, a severe autoimmune blistering disorder, following the administration of norepinephrine. Pemphigus vulgaris is characterized by flaccid and erosive blisters on the skin and mucous membranes caused by autoantibody-mediated disruption of cell adhesion, leading to increased susceptibility to infection and reduced quality of life. Norepinephrine, a potent vasoconstrictor, can cause serious irreversible vascular complications in patients with underlying autoimmune conditions.
Purpose of the Report: The interplay between autoimmune pathophysiology and vasopressor therapy, in the management of complex autoimmune conditions highlights the need for heightened clinical vigilance and individualized treatment decisions. |
Article number: 7 |
| Keywords: Pemphigus Vulgaris, Gangrene, Norepinephrine, Autoimmune Disorder |
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Full-Text [PDF 1041 kb]
(7 Downloads)
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Type of Study: case report |
Subject:
Special
Received: 2025/09/20 | Accepted: 2026/05/9 | Published: 2026/05/26
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