Effect of Chlorhexidine gluconate oral rinse on late onset ventilator associated pneumonia prevention and its interaction with severity of the illness
Journal of Critical Care Nursing : March 30, 2010, 3 (2); e7124
April 30, 2010
Article Type: Research Article
August 29, 2016
June 16, 2010
S, Alavi Majd
A, et al. Effect of Chlorhexidine gluconate oral rinse on late onset ventilator associated pneumonia prevention and its interaction with severity of the illness,
Crit Care Nurs J.
Aims: The respiratory-digestive colonization mechanism and aspiration of contaminated secretions to the lower respiratory tract are two main processes in creating mechanical ventilation associated pneumonia. This study was conducted to determine the effect of Chlorhexidine gluconate 0.2% oral rinse in preventing from late onset ventilator associated pneumonia and its interactive effect on disease severity. Methods: In this clinical trial, 80 newly admitted patients of general intensive care unit (ICU) of Loqman-e-Hakim hospital were selected randomly and were divided into two groups. Patients of experimental and control groups received Chlorhexidine oral rinse and normal saline oral rinse, twice daily. Ventilator associated pneumonia was diagnosed by Modified Clinical Pulmonary Infection Score (MCPIS). Results: The overall incidence of late VAP was 16.25% (5 VS 25% in experimental and control groups, respectively). Fisher’s exact test showed a significant differences between two groups (p<0.05). Average score of illness severity in experimental group was 26.41 while in control group was 23.95 that implied a significant statistical difference (p<0.001). Patients with higher severity of illness did not develop VAP in experimental group. Conclusion: Selective decontamination or cleaning of digestive tract with Chlorhexidine oral rinse twice a day does not differ from normal saline in prevention of ventilator-associated pneumonia, but can reduce the late onset ventilator associated pneumonia and is effective in patients with more severe conditions.
Ventilator Associated Pneumonia, Late Artificial Ventilation, Disease Severity, Oral Rinse, Chlorhexidine
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